Dimitre Simeonov

Position: PhD Student, UCSF BMS Program

Email: Dimitre.Simeonov [at] ucsf.edu

I am originally from Bulgaria, but moved to the U.S. at the age of 8 and grew up on the East Coast. In 2009, I completed a B.S. in biomedical engineering at Rensselaer Polytechnic Institute. Shortly after graduating, I received an Intramural Research and Training Award and joined Dr. William Gahl’s group at the National Institutes of Health (NIH) to study rare and undiagnosed genetic diseases. In 2013, I left the NIH to begin my graduate training in biomedical sciences at UCSF. My primary research interests are at the intersection of transcriptional regulation and human disease.

…when I am not working I am usually playing soccer.

Revisiting IL-2: Biology and therapeutic prospects
Abbas AK, Trotta E, R Simeonov D, Marson A, Bluestone JA. Sci Immunol. 2018 Jul 6;3(25)

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Mumbach MR, Satpathy AT, Boyle EA, Dai C, Gowen BG, Cho SW, Nguyen ML, Rubin AJ, Granja JM, Kazane KR, Wei Y, Nguyen T, Greenside PG, Corces MR, Tycko J, Simeonov DR, Suliman N, Li R, Xu J, Flynn RA, Kundaje A, Khavari PA, Marson A, Corn JE, Quertermous T, Greenleaf WJ, Chang HY. Nat Genet. 2017 Nov;49(11):1602-1612.

"T-bet"-ing on autoimmunity variants
Nguyen MLT, Simeonov DR, Marson A. PLOS Genetics. 13(9); e1006924 (2017)

Discovery of stimulation-responsive immune enhancers with CRISPR activation
Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. Nature. 549; 111-115 (2017)

Generation of Knock-in Primary Human T Cells Using Cas9 Ribonucleoproteins.
Schumamn K*, Lin S*, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A. PNAS. (2015).