Dimitre Simeonov

Position: PhD Student, UCSF BMS Program

Email: Dimitre.Simeonov [at] ucsf.edu

I am originally from Bulgaria, but moved to the U.S. at the age of 8 and grew up on the East Coast. In 2009, I completed a B.S. in biomedical engineering at Rensselaer Polytechnic Institute. Shortly after graduating, I received an Intramural Research and Training Award and joined Dr. William Gahl’s group at the National Institutes of Health (NIH) to study rare and undiagnosed genetic diseases. In 2013, I left the NIH to begin my graduate training in biomedical sciences at UCSF. My primary research interests are at the intersection of transcriptional regulation and human disease.

…when I am not working I am usually playing soccer.

miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. Cell Rep. 2019 Aug 20;28(8):2169-2181.

A large CRISPR-induced bystander mutation causes immune dysregulation.
Simeonov DR, Brandt AJ, Chan AY, Cortez JT, Li Z, Woo JM, Lee Y, Carvalho CMB, Indart AC, Roth TL, Zou J, May AP, Lupski JR, Anderson MS, Buaas FW, Rokhsar DS, Marson A. Commun Biol. 2019 Feb 18;2:70.

CRISPR-Based Tools in Immunity.
Simeonov DR, Marson A. Annu Rev Immunol. 2019 Jan 30.

Thymic regulatory T cells arise via two distinct developmental programs.
Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA. Nat Immunol. 2019 Feb;20(2):195-205.

Revisiting IL-2: Biology and therapeutic prospects
Abbas AK, Trotta E, R Simeonov D, Marson A, Bluestone JA. Sci Immunol. 2018 Jul 6;3(25)

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Mumbach MR, Satpathy AT, Boyle EA, Dai C, Gowen BG, Cho SW, Nguyen ML, Rubin AJ, Granja JM, Kazane KR, Wei Y, Nguyen T, Greenside PG, Corces MR, Tycko J, Simeonov DR, Suliman N, Li R, Xu J, Flynn RA, Kundaje A, Khavari PA, Marson A, Corn JE, Quertermous T, Greenleaf WJ, Chang HY. Nat Genet. 2017 Nov;49(11):1602-1612.

"T-bet"-ing on autoimmunity variants
Nguyen MLT, Simeonov DR, Marson A. PLOS Genetics. 13(9); e1006924 (2017)

Discovery of stimulation-responsive immune enhancers with CRISPR activation
Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. Nature. 549; 111-115 (2017)

Generation of Knock-in Primary Human T Cells Using Cas9 Ribonucleoproteins.
Schumamn K*, Lin S*, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A. PNAS. (2015).