Joe Hiatt

Position: (MD/PhD Student)

Email: Joe.Hiatt [at]

I was born in Tokyo and then lived in Moscow until I was 6. Sadly, I have only American citizenship and the only Russian I know translates to "I want cookie." These early failures prepared me well for a life in science. I studied archaeology at Harvard, learning about ancient agriculture, diets and brewing through stable isotope analysis under Dr. Noreen Tuross. I then spent three years at the NIH in the lab of Dr. Tony Fauci studying the first interactions of the HIV envelope protein gp120 with host T cells. After a two-year detour to start medical school, I'm very excited to be back in lab looking at how host genetics regulate transmission, infection and latency in HIV infection.

Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells.
Leenay RT, Aghazadeh A, Hiatt J, Tse D, Roth TL, Apathy R, Shifrut E, Hultquist JF, Krogan N, Wu Z, Cirolia G, Canaj H, Leonetti MD, Marson A, May AP, Zou J. Nat Biotechnol. 2019 Sep;37(9):1034-1037.

CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions.
Hultquist JF, Hiatt J, Schumann K, McGregor MJ, Roth TL, Haas P, Doudna JA, Marson A Krogan NJ. Nat Protoc. 2019 Jan;14(1):1-27.

Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device.
Mocciaro A, Roth TL, Bennett HM, Soumillon M, Shah A, Hiatt J, Chapman K, Marson A, Lavieu G. Commun Biol. 2018 May 3;1:41.

CRL4(AMBRA1) targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.
Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. EMBO J. 2018 Sep 14;37(18).

Reprogramming human T cell function and specificity with non-viral genome targeting
Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel J, Pellerin L, Carmody D, Alkorta-Aranburu G, del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. Nature. 2018 Jul;559(7714):405-409.