Position: Post-doctoral Fellow
I grew up in Melbourne, Australia and completed my PhD studies in Prof. Stephen Turner’s laboratory at the University of Melbourne in 2015. During my graduate studies, I primarily focused on understanding the role of transcription factors and epigenetic mechanisms in modulating the transcription of CD8+ T cell’s effector genes. I’ve recently joined the Marson lab in February 2016 and I’m hoping to spend my postdoc training to further broaden my understanding of the transcriptional regulation of human T cell differentiation.
When experiments go wrong in the lab, I would do some baking to keep me sane!!
Landscape of stimulation-responsive chromatin across diverse human immune cells.
Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, Marson A, Pritchard JK. Nat Genet. 2019 Sep 30.
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.
Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA. Immunity. 2019 Feb 19;50(2):362-377.
Multiplexed droplet single-cell RNA-sequencing using natural genetic variation
Kang HM, Subramaniam M, Targ S, Nguyen M, Maliskova L, McCarthy E, Wan E, Wong S, Byrnes L, Lanata CM, Gate RE, Mostafavi S, Marson A, Zaitlen N, Criswell LA, Ye CJ. Nat Biotechnol. 2018 Jan;36(1):89-94.
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Mumbach MR, Satpathy AT, Boyle EA, Dai C, Gowen BG, Cho SW, Nguyen ML, Rubin AJ, Granja JM, Kazane KR, Wei Y, Nguyen T, Greenside PG, Corces MR, Tycko J, Simeonov DR, Suliman N, Li R, Xu J, Flynn RA, Kundaje A, Khavari PA, Marson A, Corn JE, Quertermous T, Greenleaf WJ, Chang HY. Nat Genet. 2017 Nov;49(11):1602-1612.
"T-bet"-ing on autoimmunity variants
Nguyen MLT, Simeonov DR, Marson A. PLOS Genetics. 13(9); e1006924 (2017)
Discovery of stimulation-responsive immune enhancers with CRISPR activation
Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. Nature. 549; 111-115 (2017)