Selected Publications

Landscape of stimulation-responsive chromatin across diverse human immune cells.
Calderon D*, Nguyen MLT*, Mezger A*, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, Marson A, Pritchard JK. Nat Genet. 2019 Sep 30.

Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells.
Leenay RT, Aghazadeh A, Hiatt J, Tse D, Roth TL, Apathy R, Shifrut E, Hultquist JF, Krogan N, Wu Z, Cirolia G, Canaj H, Leonetti MD, Marson A, May AP, Zou J. Nat Biotechnol. 2019 Sep;37(9):1034-1037.

A large CRISPR-induced bystander mutation causes immune dysregulation.
Simeonov DR*, Brandt AJ*, Chan AY, Cortez JT, Li Z, Woo JM, Lee Y, Carvalho CMB, Indart AC, Roth TL, Zou J, May AP, Lupski JR, Anderson MS, Buaas FW, Rokhsar DS, Marson A. Commun Biol. 2019 Feb 18;2:70.

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.
Shifrut E*, Carnevale J*, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A. Cell 2018 Dec; 175:1-14.

Reprogramming human T cell function and specificity with non-viral genome targeting
Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel J, Pellerin L, Carmody D, Alkorta-Aranburu G, del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. Nature. 2018 Jul;559(7714):405-409.

"T-bet"-ing on autoimmunity variants
Nguyen MLT*, Simeonov DR*, Marson A. PLOS Genetics. 13(9); e1006924 (2017)

Discovery of stimulation-responsive immune enhancers with CRISPR activation
Simeonov DR*, Gowen BG*, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A‡. Nature. 549; 111-115 (2017)

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human Cells.
Hulquist J*, Schumann K*, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ‡, Marson A. Cell Reports.17; 138-1452 (2016).

Generation of Knock-in Primary Human T Cells Using Cas9 Ribonucleoproteins.
Schumamn K*, Lin S*, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA‡, Marson A‡. PNAS. (2015). 
     See: coverage in The Independent 

Genetic Basis of Autoimmunity.
Marson A‡, Housley WJ, Hafler DA‡. J Clin Invest. 125, 2234-2241 (2015).

The Chromatin-Modifying Enzyme Ezh2 is Critical for the Maintenance of Regulatory T Cell Identity After Activation.
DuPage M, Chopra A, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang, R, Turka L, Marson A, Bluestone JA‡. Immunity. 42, 1-12 (2015).

Genetic and Epigenetic Fine Mapping of Causal Autoimmune Disease Variants.
Farh KK*, Marson A*‡, Zhu J,  Kleinewietfeld M, Housley  WJ, Beik S,  Shoresh N , Whitton H, Ryan RJH, Shishkin AA, Hatan, M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA,  De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Nature. 518, 337-343 (2015).
     See: Research Highlight in Nature Reviews Genetics and Preview in Immunity

Decreased RORC-dependent Silencing of Prostaglandin Receptor EP2 Induces Autoimmune Th17 cells.
Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA‡. J Clin Invest. 124, 2513-2522 (2014).

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms.
Xiao S*, Yosef N*, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai P, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A‡, Kuchroo VK‡. Immunity. 40, 477-489 (2014).
      See: Preview in Immunity

Transcriptional Function of Cyclin D1 Upstream of Notch Revealed by a "Genetic-proteomic" Screen.
Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom D, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P‡. Nature. 463, 374-378 (2010).

Connecting MicroRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells.
Marson A*, Levine SS*, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA‡. Cell. 135, 521-533 (2008). 
     See: coverage in The New York Times and Editors' Choice in Science

Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency.
Marson A*, Foreman R*, Chevalier B*, Bilodeau S, Kahn M, Young RA‡, Jaenisch R‡. Cell Stem Cell. 3, 132-135, (2008).
     See: Preview in Cell Stem Cell

Foxp3 Occupancy and Regulation of Key Target Genes During T-cell Stimulation.
Marson A*, Kretschmer K*, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H‡, Young RA‡. Nature. 445, 931-935 (2007).
     See: Selected coverage in Newsweek and The Washington Post 

PML Bodies Control the Nuclear Dynamics and Function of the CHFR Mitotic Checkpoint Protein.
Daniels MJ, Marson A, Venkitaraman AR‡. Nat Struct Mol Biol. 11, 1114-1121, (2004).

*Co-First Author, ‡Corresponding Author