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 T-cell differentation

Our group employs an integrative genomics approach to decode the genetic programs governing CD4+ T-cell sub-specialization. We study the molecular circuitry that governs differentiation of pro-inflammatory and regulatory T cells, and the ways in which mutations affecting this circuitry contribute to immune dysregulation in human disease. We aim to connect the transcriptional regulatory circuitry of T cells to human genetic studies and functional genomic screens to advance understanding of specialized CD4+ T-cell functions and potentially generate novel therapeutic strategies for immune-mediated diseases.