Selected Publications

"T-bet"-ing on autoimmunity variants
Nguyen MLT, Simeonov DR, Marson A. PLOS Genetics. 13(9); e1006924 (2017)

Discovery of stimulation-responsive immune enhancers with CRISPR activation
Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. Nature. 549; 111-115 (2017)

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A. Scientific Reports. 7; 737 (2017)

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors
Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD. Nature Genetics. 49; 193–203 (2017).

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human Cells.
Hulquist J*, Schumann K*, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ‡, Marson A. Cell Reports.17; 138-1452 (2016).

A tissue checkpoint regulates type 2 immunity.
Van Dyken SJ*, Nussbaum JC*, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM‡. Nature Immunology (2016).

Generation of Knock-in Primary Human T Cells Using Cas9 Ribonucleoproteins.
Schumamn K*, Lin S*, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA‡, Marson A‡. PNAS. (2015). 
     See: coverage in The Independent 

Genetic Basis of Autoimmunity.
Marson A‡, Housley WJ, Hafler DA‡. J Clin Invest. 125, 2234-2241 (2015).

The Chromatin-Modifying Enzyme Ezh2 is Critical for the Maintenance of Regulatory T Cell Identity After Activation.
DuPage M, Chopra A, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang, R, Turka L, Marson A, Bluestone JA‡. Immunity. 42, 1-12 (2015).

Genetic and Epigenetic Fine Mapping of Causal Autoimmune Disease Variants.
Farh KK*, Marson A*‡, Zhu J,  Kleinewietfeld M, Housley  WJ, Beik S,  Shoresh N , Whitton H, Ryan RJH, Shishkin AA, Hatan, M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA,  De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Nature. 518, 337-343 (2015).
     See: Research Highlight in Nature Reviews Genetics and Preview in Immunity

Decreased RORC-dependent Silencing of Prostaglandin Receptor EP2 Induces Autoimmune Th17 cells.
Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA‡. J Clin Invest. 124, 2513-2522 (2014).

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms.
Xiao S*, Yosef N*, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai P, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A‡, Kuchroo VK‡. Immunity. 40, 477-489 (2014).
      See: Preview in Immunity

Transcriptional Function of Cyclin D1 Upstream of Notch Revealed by a "Genetic-proteomic" Screen.
Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom D, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P‡. Nature. 463, 374-378 (2010).

Connecting MicroRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells.
Marson A*, Levine SS*, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA‡. Cell. 135, 521-533 (2008). 
     See: coverage in The New York Times and Editors' Choice in Science

Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency.
Marson A*, Foreman R*, Chevalier B*, Bilodeau S, Kahn M, Young RA‡, Jaenisch R‡. Cell Stem Cell. 3, 132-135, (2008).
     See: Preview in Cell Stem Cell

Foxp3 Occupancy and Regulation of Key Target Genes During T-cell Stimulation.
Marson A*, Kretschmer K*, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H‡, Young RA‡. Nature. 445, 931-935 (2007).
     See: Selected coverage in Newsweek and The Washington Post 

PML Bodies Control the Nuclear Dynamics and Function of the CHFR Mitotic Checkpoint Protein.
Daniels MJ, Marson A, Venkitaraman AR‡. Nat Struct Mol Biol. 11, 1114-1121, (2004).

*Co-First Author, ‡Corresponding Author